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Articles

A Multidisciplinary Approach to Treating Multicentric Carpotarsal Osteolysis

When a 2-year-old girl was diagnosed with multicentric carpotarsal osteolysis, or MCTO, doctors led a multidisciplinary effort to slow its progression and advance the research of this rare genetic disease.

Articles

Closed-loop Artificial Pancreas for Type 1 Diabetes Management

Closed-loop pancreas systems are revolutionizing Type 1 diabetes management with outstanding glucose control and insulin delivery. In this article, Paul Wadwa, MD, shares the encouraging results from a 13-week trial with the Beta Bionics iLet® Bionic Pancreas.

Articles

Oncofertility in Patients With Wilms Tumor

In this paper, researchers provide a review of evidence on future fertility after Films tumor treatment and options, considerations and recommendations for fertility preservation.

Articles

Detection of Coarctation of the Aorta Using Speckle-Tracking Imaging

Researchers identified 28 variables that separate true-positive from false-positive newborns with coarctation of the aorta (CoA). Using these variables, they achieved 96% sensitivity and a 4% false-positive rate for CoA.

Articles

Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma

Neuro-oncology researchers found several mutations that can lead low- and high-grade gliomas to be resistant to BRAF/MEK inhibitors and developed combination therapies for testing in clinical trials that could be used against drug-resistant tumors.

Articles

Living-Donor Liver Transplant Center Volume Influences Waiting List Survival

Increasing access and listing, or multilisting, at high-volume pediatric liver transplant centers with expertise in living donor liver transplants and deceased donor partial liver transplants could optimize waiting lists and post-transplant outcomes.

Articles

Rare and Risky: Fetal Pericardial Teratoma Resection Surgery In Utero

To save a fetus with a dangerous mass on its heart, Children’s Hospital Colorado surgeons undertook a rare and unique surgery. The team removed the tumor while the fetus remained in utero, saving its life and the life of its mother.

Articles

Type 2 Diabetes Trends in the COVID Era

A consortium of researchers across multiple institutions explored the link between the COVID-19 pandemic and an unprecedented rise in Type 2 diabetes in children.

Articles

Psychosexual Care of Adolescent and Young Adult (AYA) Cancer Survivors

Cancer and its treatment can often delay life experiences, but access to psychosexual care during and after cancer treatment is important for improving cancer survivors’ wellbeing.

Articles

NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas

Diffuse midline glioma, a pediatric brainstem tumor, is almost always fatal. But for a small percentage of patients that have a NTRK gene mutation, TRK inhibition may provide clinical effectiveness.