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Articles

Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma

Neuro-oncology researchers found several mutations that can lead low- and high-grade gliomas to be resistant to BRAF/MEK inhibitors and developed combination therapies for testing in clinical trials that could be used against drug-resistant tumors.

Articles

Living-Donor Liver Transplant Center Volume Influences Waiting List Survival

Increasing access and listing, or multilisting, at high-volume pediatric liver transplant centers with expertise in living donor liver transplants and deceased donor partial liver transplants could optimize waiting lists and post-transplant outcomes.

Articles

Rare and Risky: Fetal Pericardial Teratoma Resection Surgery In Utero

To save a fetus with a dangerous mass on its heart, Children’s Hospital Colorado surgeons undertook a rare and unique surgery. The team removed the tumor while the fetus remained in utero, saving its life and the life of its mother.

Articles

Type 2 Diabetes Trends in the COVID Era

A consortium of researchers across multiple institutions explored the link between the COVID-19 pandemic and an unprecedented rise in Type 2 diabetes in children.

Articles

Psychosexual Care of Adolescent and Young Adult (AYA) Cancer Survivors

Cancer and its treatment can often delay life experiences, but access to psychosexual care during and after cancer treatment is important for improving cancer survivors’ wellbeing.

Articles

NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas

Diffuse midline glioma, a pediatric brainstem tumor, is almost always fatal. But for a small percentage of patients that have a NTRK gene mutation, TRK inhibition may provide clinical effectiveness.

Articles

Modulation of Surface CD11c Expression Tracks Plasticity in Murine Intestinal Tissue Eosinophils

In this study, researchers from the Gastrointestinal Eosinophilic Diseases Program in the Digestive Health Institute sought to characterize eosinophils by subgroup, using the expression of CD11c as a framework.

Articles

Primary vs. Salvage Liver Transplantation for Biliary Atresia: A Retrospective Cohort Study

Kasai hepatoportoenterostomy is the standard of care for children with biliary atresia to help relieve the bile duct blockage. Many children may still require a liver transplant. In this study, researchers compared the benefits of the Kasai procedure versus receiving a primary liver transplant.

Articles

Early Outcomes of a Myofascial Repair Technique for Fetal Meningocele

In this study, researchers compared the results from two closure methods for repairing myelomeningocele and myeloschisis: modified-myofascial closure and non-myofascial closure.

Articles

Improved Survival for Infants with Severe Congenital Diaphragmatic Hernia

A Colorado Fetal Care Center study found greater survival among infants with severe congenital diaphragmatic hernia when they receive early intervention with ECMO from high-volume medical centers with a protocoled care approach.