Children's Hospital Colorado
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Articles

Serotonin-Deficient Neonatal Murine Models Not Protected Against Hypoxia-Induced Bronchopulmonary Dysplasia or Pulmonary Hypertension

Learn why our researchers were surprised find neonates with pulmonary hypertension associated with bronchopulmonary dysplasia won’t likely benefit from genetic or pharmacologic inhibition of TPH1.

Articles

Rectus Femoris Transfer, With or Without Hamstring Lengthening, Does Not Change Hip Kinematics in Children with Cerebral Palsy

Children with cerebral palsy who undergo rectus femoris transfer with or without hamstring lengthening may experience improvement in stiff-knee gait but won’t see improvement in hip kinematics.

Articles

Twelve-Week Standard of Care Pavlik Harness Treatment Longer than Median Time to Normalization

Some infants diagnosed with IIc hip dysplasia may not need the standard 12 weeks of Pavlik bracing to achieve normalized hips. Learn about how femoral head coverage and instability may be better indicators for determining bracing duration.

Articles

Fetal Megacystis and Multisystem Smooth Muscle Dysfunction Syndrome

Case report of fetal megacystis due to ACTA2 variant as the cause of Multisystemic smooth muscle dysfunction syndrome, or MSMDS, demonstrates underlying etiology of megacystis may be broader than thought.

Articles

Current Classification Systems Adequately Assess Severity and Management Patterns of Pediatric Pelvic Fractures

Pediatric pelvic ring and acetabular fractures are rare but serious injuries. A 10-year retrospective study looked at the effectiveness of injury classification tools in determining severity and assisting orthopedic specialists in injury management.

Articles

Evaluating Kidney Function Decline in Children with Chronic Kidney Disease

Researchers studying children with chronic kidney disease used a massive EHR database to evaluate risk factors for decline in kidney function, confirming other previous study findings.

Articles

HEROS: An Early Remote SARS-CoV-2 Study of Households with Children

An early, 12-city remote study of SARS-CoV-2 infection within U.S. households with children. HEROS used sample self-collection for detection of viral RNA in nasal secretions to gauge infection rate and transmission in families.

Articles

Speeding Up Cardiac Disease Research with Big Data

Researchers at Children's Hospital Colorado's Pediatric Heart Institute are utilizing big data to speed up discovery. By adopting business world techniques, the researchers apply a data-driven, inductive approach, using blood tests to measure biomarkers and machine learning to sort the data, leading to the development of new research questions and speeding up the discovery process.

Articles

Transforming Pediatric Mental Health Care

The team at Children's Hospital Colorado is radically transforming pediatric mental health care to address the rising mental health crisis among kids. Their comprehensive approach includes implementing a trauma-informed care system, reducing inpatient care wait times, significantly expanding outpatient services and more.

Articles

More Extensive Lymph Node Sampling During Pediatric Renal Tumor Surgery Does Not Increase Postoperative Complications

Concerns about risk has led to low lymph node sampling rates during renal tumor surgeries despite value for treatment and disease staging. This study found it caused no rise in complications.